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MI prize-winner of the 3rd call for projects Hospital-University Research in health

Agnès BUZYN, Minister of Health and Solidarity, Frédérique VIDAL, Minister of Higher Education Research and Innovation and Louis SCHWEITZER General Commissioner for Investment have announced the ten winners of the third call for projects Hospital-University Research in health, including the PIONeeR project of Marseille Immunopole.

PIONeeR aims to overcome the resistance to anti-PD-1 therapies in advanced Non-Small Cell Lung Cancer (NSCLC) through a global strategy based on:

  • a comprehensive biomarkers assessment on tumor biopsies;
  • an early-phase randomized clinical trial comparing several a new Immune Checkpoint Inhibitors (ICI) combination and a control arm (docetaxel) for patients with tumors progressing within 12 weeks of anti-PD-1 treatment initiation;
  • the development and validation of new ICI candidates.

PIONeeR brings together cutting-edge projects from MI-FHU leaders in academic (E. Vivier, B. Malissen, D. Olive), translational (F. Romagné) and clinical (F. Barlesi) immuno-oncology, with important contributions from industrial and academic partners (AstraZeneca, Innate-Pharma, HalioDX, Imcheck Therapeutics, Novadiscovery and Centre Leon Berard).