MI should enable us to accelerate discovery, enhance our treatment options and offer more innovative options to our patients through current clinical trials and those of the future.
In less than a decade, cancer diagnosis and treatment has progressed considerably. As in many other cancers, “histologic historical classification” of lung tumors into sub-types (squamous cell, adenocarcinoma, large or small carcinoma cells) was disrupted by the advent of molecular profiling. Today, more than a dozen forms of lung tumors have been identified based on molecular alterations leading to bio-guided treatments, marketed or under development, with a significant improvement in survival. Furthermore, by unlocking the immune system of patients, new immunotherapy antibodies have allowed spectacular survival rates in some advanced forms of cancer.
At this time, many of these drugs are still in the development phase. The first goal is to facilitate patient access to these new options. In response, we have created two APHM services exclusively dedicated to the early transfer of these innovations. Each year, over 600 patients with metastatic lung cancers access this type of treatments including over 200 in the context of trials investigating new drugs or new strategies, of which almost half currently based on immunotherapies. The second goal is obviously to optimize and accelerate the development of these innovations, particularly immunotherapies. To date, only about 20% patients respond to these treatments. With researchers and industrials, we are seeking ways to identify in advance those responders using biomarkers, understand the mechanisms of resistance to current treatments and test new therapeutic combinations able to circumvent these resistances.
At the interface of the laboratory and the patient’s bed, these projects require expertise and interdisciplinarity, highlighted in the collective Marseille Immunopole. MI should enable us to accelerate discovery, enhance our treatment options and offer more innovative options to our patients through current clinical trials and those of the future.#clinique
For many years our service at the Timone Hospital has collaborated with researchers including the " Natural Killer Cells and Innate Immunity" team of Eric VIVIER .
MI today is a great accomplishment as it brings together for the first time all the expertise in immunology but it is above a new strategic step for all Marseille immunology players
The laboratory's mission therefore reflects that of the Marseille Immunopôle: to lead the development of these innovations, from the initial discovery to the proof of concept in clinical setting.
Diagnostic in immuno-oncology is an innovative field combining the latest discoveries in immunology and new imaging technologies, such as digital pathology.