Understanding its mechanisms of action and proposing new diagnostic and therapeutic solutions is the ambitious project that we set with my team.
During my research career, I became interested in different proteins involved in pathophysiological processes. Amongst them, the CD146 molecule, on which my team has worked for many years, is particularly exciting because it is both yin and yang, with involvement in many physiological processes such as angiogenesis or embryo implantation and, at the same time, a deleterious effect when expressed on tumour cells.
Understanding its mechanisms of action and proposing new diagnostic and therapeutic solutions is the ambitious project that we set with my team. To achieve this, we combine multiple and cross-cutting approaches from genes to proteins, from animal model cell tissue to humans, and from fundamental research to clinical application. This requires the use of advanced technology from transcriptomics proteomics, through imagery and the generation of antibodies. Marseille Immunopole is an extraordinary melting pot that allows us to work with many experts and combine these different approaches, with the common goal to bring new tests and new drugs for the benefit of patients.#recherche
The thrust of MI is the ability of Marseille researchers, clinicians and industrials to play as a team.
“Our immunotherapy antibodies are positioned at the crossroads of two immunology fields with high potential: the g9d2 T cells and a novel superfamily of immunomodulators, butyrophilins”
We have developed a library of human tumors xenografted on immunodepressed mice
Michel IOVANNA JUAN
AMU, IPC, CRCM
The Explore covid-19 project was born from combining the forces of Marseille Immunopôle. It should lead us to better understand this new disease and improve the prognosis of our patients.